List of Government Acronyms: S
| Acronym | Agency/Organization/Definition |
| SAARC | South Asian Association for Regional Cooperation |
| SACEP | South Asia Co-operative Environment Programme |
| SACU | Southern Africa Customs Union |
| SADC | Southern African Development Community |
| SADCC | Southern Africa Development Coordination Conference |
| SAFE | South African Far East Cable |
| SBA | Small Business Administration |
| SCO | Shanghai Cooperative Organization |
| SEC | Security and Exchange Commision |
| SELA | Sistema Economico Latinoamericana; see Latin American Economic System (LAES) |
| SIC | Standard Industrial Classification |
| SPARTECA | South Pacific Regional Trade and Economic Cooperation Agreement |
| SPC | South Pacific Commision |
| SPF | South Pacific Forum |
| SSA | Social Security Administration |
| Stat. | United States Statutes at Large |
| STIS | Science and Technology Information System |
| SuDoc | Superintendent of Documents |
